BDBM50569979 CHEMBL4875028

SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n([C@@H]3CC[C@@H](CC3)NC(=O)C3CCCCC3)c2n1)N1CCN(C)CC1

InChI Key InChIKey=CLYMONPGUOMIQL-PLQXJYEYSA-N

Data  1 IC50  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50569979   

TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50569979(CHEMBL4875028)
Affinity DataKd:  0.150nMAssay Description:Binding affinity to wild-type human partial length TTK (N505 to V798 residues) expressed in bacterial expression system by active site-directed compe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50569979(CHEMBL4875028)
Affinity DataIC50:  23nMAssay Description:Inhibition of recombinant full-length human TTK using MBP as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50569979(CHEMBL4875028)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to wild-type human partial length PIK3CD (R108 to Q1044 residues) expressed in HEK293 cells by active site-directed competition bind...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50569979(CHEMBL4875028)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to wild-type human partial length IRAK1 (R194 to S712 residues) expressed in mammalian expression system by active site-directed com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP/microtubule affinity-regulating kinase 3(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50569979(CHEMBL4875028)
Affinity DataKd:  11nMAssay Description:Binding affinity to wild-type human full length MARK3 (M1 to L729 residues) expressed in bacterial expression system by measuring active site-directe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase C2 domain-containing subunit gamma(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50569979(CHEMBL4875028)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human partial length PIK3C2G (M1 to I1446 residues) expressed in mammalian expression system by active site-directed competition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDeath-associated protein kinase 3(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50569979(CHEMBL4875028)
Affinity DataKd:  13nMAssay Description:Binding affinity to wild-type human partial length DAPK3 (M1 to A277 residues) expressed in bacterial expression system by measuring active site-dire...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed