BDBM50571528 CHEMBL4846435
SMILES NC(=O)c1ccc2N(Cc3ccc(cc3)C(=O)NO)CCCc2c1
InChI Key InChIKey=ZRFMDXMQBRKKOA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50571528
Affinity DataIC50: 0.700nMAssay Description:Inhibition of recombinant human HDAC6 using Ac-GAK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 30...More data for this Ligand-Target Pair
Affinity DataIC50: >100nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 651nMAssay Description:Inhibition of recombinant human HDAC8 using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant human HDAC2 using Ac-GAK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 30...More data for this Ligand-Target Pair
Affinity DataIC50: 235nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-GAK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 30...More data for this Ligand-Target Pair
Affinity DataIC50: 454nMAssay Description:Inhibition of recombinant human HDAC4 using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 276nMAssay Description:Inhibition of recombinant human HDAC5 using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 109nMAssay Description:Inhibition of recombinant human HDAC7 using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Inhibition of recombinant human HDAC9 using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of Illinois At Chicago
Curated by ChEMBL
University Of Illinois At Chicago
Curated by ChEMBL
Affinity DataIC50: 5.31E+3nMAssay Description:Inhibition of recombinant human HDAC11 expressed in HEK293T/17 cells using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Affinity DataIC50: 4.83E+3nMAssay Description:Inhibition of Nanoluc-fused HDAC1 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NANOBRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of Nanoluc-fused HDAC6 CD2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NANOBRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 140nMAssay Description:Inhibition of HDAC6 in human RPMI-8226 cells assessed as increase in tubulin acetylation incubated for 6 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >100nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >100nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >100nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 356nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-GAK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 30...More data for this Ligand-Target Pair