BDBM50572395 CHEMBL4864387
SMILES Fc1cnc(Nc2ccc3n(ccc3c2)S(=O)(=O)C(F)(F)F)nc1-c1cnn(CCC#N)c1
InChI Key InChIKey=CGDRNYQWTORWBT-UHFFFAOYSA-N
Data 13 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 50572395
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 157nMAssay Description:Inhibition of recombinant human JAK2 (808 to end residues) KTFCGTPEYLAPE as substrate measured after 40 mins in presence of [gamm33P]ATP by scintilla...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human TYK2 (875 to end residues) using GGMEDIYFEFMGG as substrate incubated for 40 mins in presence of [gamma33P]ATP by sci...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human JAK1 (866 to end residues) using GEEPLYWSFPAKKK as substrate after 40 mins in presence of [gamma33P]ATP by scintillation counting...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant human JAK3 (781 to end residues) using GGEEEEYFELVKKKK as substrate measured after 40 mins in presence of [gamma33P]ATP by ...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 91nMAssay Description:Inhibition of TYK2/JAK1 signaling pathway in human whole blood assessed as reduction in IFN-alpha induced STAT3 phosphorylation incubated for 60 mins...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK2(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of JAK2/TYK2 signaling pathway in human whole blood assessed as reduction in IL-12 induced STAT4 phosphorylation incubated for 60 mins fol...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibition of JAK1/JAK3 signaling pathway in human whole blood assessed as reduction in IL-21 induced STAT3 phosphorylation incubated for 60 mins fol...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1/JAK2(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation incubated for 60 mins fol...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 157nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK2(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 652nMAssay Description:Inhibition of JAK2/TYK2 signaling pathway in human whole blood assessed as reduction in IL-23 induced STAT3 phosphorylation incubated for 60 mins fol...More data for this Ligand-Target Pair