BDBM50572395 CHEMBL4864387

SMILES Fc1cnc(Nc2ccc3n(ccc3c2)S(=O)(=O)C(F)(F)F)nc1-c1cnn(CCC#N)c1

InChI Key InChIKey=CGDRNYQWTORWBT-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50572395   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572395(CHEMBL4864387)
Affinity DataIC50:  157nMAssay Description:Inhibition of recombinant human JAK2 (808 to end residues) KTFCGTPEYLAPE as substrate measured after 40 mins in presence of [gamm33P]ATP by scintilla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572395(CHEMBL4864387)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant human TYK2 (875 to end residues) using GGMEDIYFEFMGG as substrate incubated for 40 mins in presence of [gamma33P]ATP by sci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572395(CHEMBL4864387)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human JAK1 (866 to end residues) using GEEPLYWSFPAKKK as substrate after 40 mins in presence of [gamma33P]ATP by scintillation counting...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572395(CHEMBL4864387)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant human JAK3 (781 to end residues) using GGEEEEYFELVKKKK as substrate measured after 40 mins in presence of [gamma33P]ATP by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572395(CHEMBL4864387)
Affinity DataIC50:  91nMAssay Description:Inhibition of TYK2/JAK1 signaling pathway in human whole blood assessed as reduction in IFN-alpha induced STAT3 phosphorylation incubated for 60 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK2(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572395(CHEMBL4864387)
Affinity DataIC50:  50nMAssay Description:Inhibition of JAK2/TYK2 signaling pathway in human whole blood assessed as reduction in IL-12 induced STAT4 phosphorylation incubated for 60 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572395(CHEMBL4864387)
Affinity DataIC50:  9nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572395(CHEMBL4864387)
Affinity DataIC50:  1.61E+3nMAssay Description:Inhibition of JAK1/JAK3 signaling pathway in human whole blood assessed as reduction in IL-21 induced STAT3 phosphorylation incubated for 60 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1/JAK2(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572395(CHEMBL4864387)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of JAK1/JAK2 signaling pathway in human whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation incubated for 60 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572395(CHEMBL4864387)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572395(CHEMBL4864387)
Affinity DataIC50:  157nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572395(CHEMBL4864387)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK2(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572395(CHEMBL4864387)
Affinity DataIC50:  652nMAssay Description:Inhibition of JAK2/TYK2 signaling pathway in human whole blood assessed as reduction in IL-23 induced STAT3 phosphorylation incubated for 60 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed