BDBM50572911 CHEMBL4852677

SMILES Nc1ncnc2n(cc([C@@H]3CCCO3)c12)[C@@H]1O[C@H](COc2ccc3ccc(nc3c2)N2CCC2)[C@@H](O)[C@@H]1F

InChI Key InChIKey=NRQAURCOIDGAEQ-YUSZHSHMSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50572911   

TargetN6-adenosine-methyltransferase catalytic subunit(Homo sapiens)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50572911(CHEMBL4852677)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of METTL3-mediated m6A methylation in human MOLM-3 cells assessed as reduction in mRNA level measured after 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Homo sapiens)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50572911(CHEMBL4852677)
Affinity DataIC50: <10nMAssay Description:Inhibition of METTL3 (unknown origin) using 3' biotinylated RNA (UCUGGACUAAA) and 3H-SAM as a substrate preincubated for 5 mins followed by substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed