BDBM50573222 CHEMBL4869634

SMILES CC(C)Oc1cc(F)ccc1Nc1ncnc2ccc(nc12)-c1ccc(cc1)C(=O)N1CCNCC1

InChI Key InChIKey=FWTKVRZMQJINSD-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50573222   

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50573222(CHEMBL4869634)
Affinity DataIC50:  1nMAssay Description:Inhibition of MKN1 (unknown origin) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50573222(CHEMBL4869634)
Affinity DataIC50:  7nMAssay Description:Inhibition of MKN2 (unknown origin) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50573222(CHEMBL4869634)
Affinity DataIC50:  1nMAssay Description:Inhibition of wild type human full length MKN1 (M1 to L424) expressed in mammalian expression system by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50573222(CHEMBL4869634)
Affinity DataIC50:  7nMAssay Description:Inhibition of wild type human partial length MKN2 (G63 to S388 residues) expressed in mammalian expression system by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50573222(CHEMBL4869634)
Affinity DataIC50:  43nMAssay Description:Inhibition of full length recombinant human PIM1 using KKRNRTLTV as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50573222(CHEMBL4869634)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human EGFR T790M mutant (696 to end residues) using GGMEDIYFEFMGG as substrate after 40 mins in presence of [gamma-33ATP] b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50573222(CHEMBL4869634)
Affinity DataIC50:  774nMAssay Description:Inhibition of recombinant human Pim3 (2 to end residues) using RSRHSSYPAGT as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50573222(CHEMBL4869634)
Affinity DataIC50:  1.97E+3nMAssay Description:Inhibition of recombinant human EGFR (696 to end residues) using poly(Glu, Tyr) 4:1 as substrate after 40 mins in presence of [gamma-33ATP] by radiom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50573222(CHEMBL4869634)
Affinity DataIC50:  2.22E+3nMAssay Description:Inhibition of recombinant human B-Raf (416 to end residues) using myelin as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by radiome...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50573222(CHEMBL4869634)
Affinity DataIC50:  7.49E+3nMAssay Description:Inhibition of ERBB2 (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50573222(CHEMBL4869634)
Affinity DataIC50:  232nMAssay Description:Inhibition of recombinant human Pim2 (2 to end residues) using RSRHSSYPAGT as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed