BDBM50574708 CHEMBL4866102
SMILES C(Oc1cccc(c1)-c1nc2sccn2c1-c1ccncn1)c1ccccc1
InChI Key InChIKey=GKFYUJHVBXYBEI-UHFFFAOYSA-N
Data 14 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50574708
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of ErbB4 (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of wild type B-RAF (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase A-Raf(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 7.06E+3nMAssay Description:Inhibition of A-RAF (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 4.35E+3nMAssay Description:Inhibition of EGFR- L861Q mutant (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting met...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibition of EGFR- T790M mutant (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting met...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 8.56E+3nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation countin...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting meth...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of MEK2 (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.28E+4nMAssay Description:Inhibition of human ERG incubated for 3 hrs by competitive fluorescence tracer binding based assayMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: >9.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin) using EOMCC as a substrate incubated for 20 mins by fluorescence based analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 2.09E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using BOMCC as a substrate incubated for 20 mins by fluorescence based analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 710nMAssay Description:Inhibition of KDR (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 2.03E+3nMAssay Description:Inhibition of RAF1 (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of FLT-3(unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair