BDBM50579811 CHEMBL5084928
SMILES C[C@]1(CC[C@](CF)(N=C1N)c1cc(NC(=O)c2cc3OCOc3cn2)ccc1F)S(C)(=O)=O
InChI Key InChIKey=IENHUNDDRIGOLX-NHCUHLMSSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50579811
Affinity DataIC50: 2.30nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys-Met/Asn-Leu mutant-derived peptide as substrate by FRET assa...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of BACE1 in human SNKBE2 cells expressing wild type APP695 assessed as reduction in amyloid beta 42 secretion incubated for 18 hrs by sand...More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of BACE2 (unknown origin) using APP harboring Swedish Lys-Met/Asn-Leu mutant-derived peptide as substrate incubated for 2 hrs by FRET assa...More data for this Ligand-Target Pair