BDBM50579860 CHEMBL5076067

SMILES COc1ccccc1Nc1ncc(Cl)c(n1)-c1cc2c([nH]1)C1(CCN(CC1)C(=O)C=C)CNC2=O

InChI Key InChIKey=FWFZHVUNVPMLSR-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50579860   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50579860(CHEMBL5076067)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) preincubated for 60 mins followed by substrate addition and further incubated for 60 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50579860(CHEMBL5076067)
Affinity DataEC50:  277nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimulation and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50579860(CHEMBL5076067)
Affinity DataEC50:  3.10nMAssay Description:Inhibition of EGF-induced phosphorylation of EGFR T790M/L858R double mutant in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50579860(CHEMBL5076067)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of wild type EGFR (unknown origin) preincubated for 60 mins followed by substrate addition and further incubated for 60 mins in presence o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed