BDBM50581355 CHEMBL5070835

SMILES Fc1cnc2OCC3(CC3)NC(=O)c3cnn4ccc(nc34)N3CCNC[C@@H]3c2c1

InChI Key InChIKey=SHRNMJSKKQHLKT-OAHLLOKOSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50581355   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581355(CHEMBL5070835)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581355(CHEMBL5070835)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of TrKA (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581355(CHEMBL5070835)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of TrKA G595R mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581355(CHEMBL5070835)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of ROS1 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581355(CHEMBL5070835)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581355(CHEMBL5070835)
Affinity DataIC50:  89nMAssay Description:Inhibition of ALK (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581355(CHEMBL5070835)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of TrKA G667C mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed