BDBM50581357 CHEMBL5093999

SMILES Fc1cnc2OCC3(CC3)NC(=O)c3cnn4ccc(nc34)N3CCCC[C@@H]3c2c1

InChI Key InChIKey=WUOOWFKJQHKXHK-MRXNPFEDSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50581357   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581357(CHEMBL5093999)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of TrKA (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581357(CHEMBL5093999)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of TrKA G595R mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581357(CHEMBL5093999)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of ROS1 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581357(CHEMBL5093999)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581357(CHEMBL5093999)
Affinity DataIC50:  19nMAssay Description:Inhibition of ALK (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581357(CHEMBL5093999)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of TrKA G667C mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed