BDBM50581548 CHEMBL5085124

SMILES [H][C@@]12CS[C@@H](CCCCC(=O)NCCOCCOCCC(=O)NC[C@@H]3NC(=O)[C@H](C)NC(=O)CCSCc4cc5CSCCNC(=O)[C@]6(C)CCCN6C(=O)[C@H](Cc6ccc(OC)cc6)NC(=O)[C@@H](NC(=O)[C@@H]6[C@@H]7CCN6C(=O)[C@H](Cc6cn(Cc8cn(nn8)-c(c5)c4)c4ccc(F)cc64)NC(=O)[C@H](Cc4cccc(C\C=C\CO7)c4)NC3=O)[C@H](C)O)[C@]1([H])NC(=O)N2

InChI Key InChIKey=DBHUWSCFNOUPCN-PRFVQGLSSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50581548   

TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581548(CHEMBL5085124)
Affinity DataKi:  0.000600nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET ultra assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581548(CHEMBL5085124)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581548(CHEMBL5085124)
Affinity DataKi: >0.129nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed