BDBM50585381 CHEMBL5080840

SMILES [H][C@]12CC[C@]([H])(CN(C1)c1nc(OC[C@@H]3CCCN3C)nc3c(F)c(ncc13)-c1cc(O)cc3ccccc13)N2

InChI Key InChIKey=DBIWGHBJXDMJBJ-ZCNNSNEGSA-N

Data  1 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50585381   

TargetGTPase KRas(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM50585381(CHEMBL5080840)
Affinity DataIC50:  530nMAssay Description:Inhibition of KRAS G12D mutant in human AGS cells assessed as reduction in ERK phosphorylation measured after 3 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGTPase KRas(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM50585381(CHEMBL5080840)
Affinity DataKd:  182nMAssay Description:Binding affinity to human AviTEV6His-tagged KRAS isoform 4B wild type (1 to 169 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissoc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB