BDBM50586746 CHEMBL5081833

SMILES CCc1ccccc1Cc1cc2cc(ccc2n1C(C)C)C(=O)NCc1ccc(cc1)S(=O)(=O)CC

InChI Key InChIKey=RGFFMHCXIJHLSM-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50586746   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586746(CHEMBL5081833)
Affinity DataEC50:  2nMAssay Description:Partial agonist activity at human RORgamma in cytostim stimulated human PBMC cells assessed as decrease in differentiation of TH17 cells by measuring...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586746(CHEMBL5081833)
Affinity DataEC50:  25nMAssay Description:Agonist activity at N-terminal GST tagged human RORgamma LBD using fluorescein-D22 as coactivator incubated for 60 mins by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed