BDBM50587669 CHEMBL5190521

SMILES CN1c2cc3ccccc3cc2C(=O)N(C)c2cnc(Nc3cnn(c3)C3CCNCC3)nc12

InChI Key InChIKey=MFWHDFGMXHATNR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50587669   

TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587669(CHEMBL5190521)
Affinity DataIC50:  30nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAurora kinase B(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587669(CHEMBL5190521)
Affinity DataIC50:  54nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAurora kinase C(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587669(CHEMBL5190521)
Affinity DataIC50:  120nMAssay Description:Inhibition of Aurora C (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587669(CHEMBL5190521)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of NUAK1 in HEK293 cells assessed as effect on MYPT1 phosphorylation at Ser445 incubated for 3 mins by immunoblotting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed