BDBM50590283 CHEMBL5169766::US20230303547, Reference Example D

SMILES O=C(Nc1ncc(s1)-c1ccccc1)[C@H]1CCN(C1)C#N

InChI Key InChIKey=DPOQOSJMDTZFOR-LBPRGKRZSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50590283   

TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
Mission Therapeutics

US Patent
LigandPNGBDBM50590283(CHEMBL5169766 | US20230303547, Reference Example D)
Affinity DataIC50:  310nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 µM for a final concentration of 100 µM) in 50% DMSO in a 96-well polypropylen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50590283(CHEMBL5169766 | US20230303547, Reference Example D)
Affinity DataIC50:  580nMAssay Description:Inhibition of GST-tagged recombinant UCHL1 (unknown origin) using Ub-Lys-TAMRA as substrate incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
Mission Therapeutics

US Patent
LigandPNGBDBM50590283(CHEMBL5169766 | US20230303547, Reference Example D)
Affinity DataIC50:  310nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 µM for a final concentration of 100 µM) in 50% DMSO in a 96-well polypropylen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50590283(CHEMBL5169766 | US20230303547, Reference Example D)
Affinity DataIC50:  550nMAssay Description:Inhibition of FLAG-tagged UCHL1 (unknown origin) expressed in CAL-51 cells using HA-Ub-VME as substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50590283(CHEMBL5169766 | US20230303547, Reference Example D)
Affinity DataIC50: >10nMAssay Description:Inhibition of GST-tagged recombinant UCHL3 (unknown origin) using Ub-Lys-TAMRA as substrate incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed