BDBM50590283 CHEMBL5169766::US20230303547, Reference Example D
SMILES O=C(Nc1ncc(s1)-c1ccccc1)[C@H]1CCN(C1)C#N
InChI Key InChIKey=DPOQOSJMDTZFOR-LBPRGKRZSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50590283
Affinity DataIC50: 310nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 µM for a final concentration of 100 µM) in 50% DMSO in a 96-well polypropylen...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 580nMAssay Description:Inhibition of GST-tagged recombinant UCHL1 (unknown origin) using Ub-Lys-TAMRA as substrate incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 µM for a final concentration of 100 µM) in 50% DMSO in a 96-well polypropylen...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 550nMAssay Description:Inhibition of FLAG-tagged UCHL1 (unknown origin) expressed in CAL-51 cells using HA-Ub-VME as substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: >10nMAssay Description:Inhibition of GST-tagged recombinant UCHL3 (unknown origin) using Ub-Lys-TAMRA as substrate incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair