BDBM50592781 CHEMBL5203413

SMILES CC#CCOc1ccc2cc(oc2c1)C(c1ccc(cc1)C#N)n1cncn1

InChI Key InChIKey=VCZRCOBTYSEEQW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50592781   

TargetAromatase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592781(CHEMBL5203413)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592781(CHEMBL5203413)
Affinity DataIC50:  2.88E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using ethoxyresorufin as substrate and measured by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592781(CHEMBL5203413)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate and measured by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592781(CHEMBL5203413)
Affinity DataIC50:  2.17E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate and measured by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592781(CHEMBL5203413)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using Dextromethorphan as substrate and measured by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50592781(CHEMBL5203413)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate and measured by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed