BDBM50593061 CHEMBL5183704

SMILES Cc1ccc(NC(=O)CCc2cccc(c2)-c2cnc3[nH]ccc3c2)cc1C(F)(F)F

InChI Key InChIKey=MCCKGEPZYYKAEX-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50593061   

TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50593061(CHEMBL5183704)
Affinity DataIC50:  47nMAssay Description:Inhibition of CDK8 (unknown origin) incubated in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50593061(CHEMBL5183704)
Affinity DataEC50:  24nMAssay Description:Inhibition of CDK8 in human HCT-116 cells assessed as reduction in STAT1 phosphorylation at S727 residue measured after 24 hrs by Western blot assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50593061(CHEMBL5183704)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of CDK8 in human HCT-116 cells transfected with TOPFlash luciferase reporter plasmid assessed as reduction in TCF/LEF transcriptional acti...More data for this Ligand-Target Pair
In DepthDetails PubMed