BDBM50593123 GENZ-682452::GZ-402671::GZ/SAR402671::GZ402671::Genz-682452::Genz-682452-AA::Gz402671::Ibiglustat::SAR-402671::SAR402671::VENGLUSTAT::Venglustat

SMILES CC(C)(NC(=O)O[C@@H]1CN2CCC1CC2)c1csc(n1)-c1ccc(F)cc1

InChI Key InChIKey=YFHRCLAKZBDRHN-MRXNPFEDSA-N

Data  8 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50593123   

TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50593123(GENZ-682452 | GZ-402671 | GZ/SAR402671 | GZ402671 ...)
Affinity DataIC50:  44nMAssay Description:In vitro inhibitory potency against human kidney renin.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50593123(GENZ-682452 | GZ-402671 | GZ/SAR402671 | GZ402671 ...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibitory activity against bovine cathepsin DMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Homo sapiens)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50593123(GENZ-682452 | GZ-402671 | GZ/SAR402671 | GZ402671 ...)
Affinity DataIC50:  500nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as SAH production by SAHH-coup...More data for this Ligand-Target Pair
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Homo sapiens)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50593123(GENZ-682452 | GZ-402671 | GZ/SAR402671 | GZ402671 ...)
Affinity DataIC50:  500nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as SAH production by SAHH-coup...More data for this Ligand-Target Pair
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Homo sapiens)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50593123(GENZ-682452 | GZ-402671 | GZ/SAR402671 | GZ402671 ...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human NTMT1 in human HCT116 cells assessed as reduction in me3-SET level incubated for 72 hrs by western blot analysisMore data for this Ligand-Target Pair
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Homo sapiens)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50593123(GENZ-682452 | GZ-402671 | GZ/SAR402671 | GZ402671 ...)
Affinity DataKd:  33nMAssay Description:Binding affinity to NTMT1 (unknown origin) assessed as dissociation constant in presence of SAM by isothermal titration calorimetry analysisMore data for this Ligand-Target Pair
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Homo sapiens)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50593123(GENZ-682452 | GZ-402671 | GZ/SAR402671 | GZ402671 ...)
Affinity DataKd:  160nMAssay Description:Binding affinity to NTMT1 (unknown origin)assessed as dissociation constant in absence of SAM by isothermal titration calorimetry analysisMore data for this Ligand-Target Pair
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Homo sapiens)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50593123(GENZ-682452 | GZ-402671 | GZ/SAR402671 | GZ402671 ...)
Affinity DataIC50:  560nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using GPKRIA as substrate preincubated ...More data for this Ligand-Target Pair
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Homo sapiens)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50593123(GENZ-682452 | GZ-402671 | GZ/SAR402671 | GZ402671 ...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human NTMT1 in human HCT116 cells assessed as reduction in me3-RCC1 level incubated for 72 hrs by western blot analysisMore data for this Ligand-Target Pair
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Homo sapiens)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50593123(GENZ-682452 | GZ-402671 | GZ/SAR402671 | GZ402671 ...)
Affinity DataIC50:  560nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as SAH production by SAHH-coup...More data for this Ligand-Target Pair