BDBM50593495 CHEMBL5196156

SMILES [H][C@]12CC[C@]([H])(CN(C1)c1nc(C)ns1)C2NC1=NC2C=CC=C(C2=N1)c1ccc(F)c(F)c1F

InChI Key InChIKey=VOROBJLBTJUGCC-GKMUEVJASA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50593495   

TargetPresenilin-1(Homo sapiens (Human))
Indian Institute Of Technology (B.H.U.)

Curated by ChEMBL

LigandBDBM50593495(CHEMBL5196156)Copy SMILESCopy InChI

Affinity DataIC50:  1nMAssay Description:Modulation of gamma-secretase (unknown origin) assessed as decrease in free Abeta42 levelsMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails PubMed
Copy BDB DOI

TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Indian Institute Of Technology (B.H.U.)

Curated by ChEMBL

LigandBDBM50593495(CHEMBL5196156)Copy SMILESCopy InChI

Affinity DataIC50:  4.5nMAssay Description:Modulation of gamma-secretase (unknown origin) assessed as decrease in total Abeta42 levelsMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails PubMed
Copy BDB DOI