BDBM50598923 CHEMBL5193821

SMILES CCn1c(CO)nn(-c2nc(O[C@@H](C)C(F)(F)F)c(cc2F)C(=O)Nc2c(C)cnc(OC)c2Cl)c1=O

InChI Key InChIKey=FJYNLQXYLQBCRQ-JTQLQIEISA-N

Data  10 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50598923   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598923(CHEMBL5193821)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598923(CHEMBL5193821)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to His fused human DHODH expressed in Escherichia coli by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598923(CHEMBL5193821)
Affinity DataIC50:  10nMAssay Description:Inhibition of mouse DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598923(CHEMBL5193821)
Affinity DataIC50:  130nMAssay Description:Inhibition of rat DHODHMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598923(CHEMBL5193821)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of hERG expressed in HEK293 cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598923(CHEMBL5193821)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598923(CHEMBL5193821)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598923(CHEMBL5193821)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598923(CHEMBL5193821)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598923(CHEMBL5193821)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598923(CHEMBL5193821)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed