BDBM506 3-({4-[bis(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]phenyl}(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl)-4-hydroxy-2H-chromen-2-one::CHEMBL293914::Cancer Chemotherapy National Service Center (CCNSC) compound 158393::NSC 158393

SMILES Oc1c(C(c2ccc(cc2)C(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)c(=O)oc2ccccc12

InChI Key InChIKey=BXKKDJUEVYKLOT-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 506   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Institutes of Health

LigandPNGBDBM506(3-({4-[bis(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]...)
Affinity DataIC50:  1.70E+3nMpH: 6.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM506(3-({4-[bis(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against HIV-1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM506(3-({4-[bis(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]...)
Affinity DataIC50:  800nMAssay Description:Inhibitory concentration against purified recombinant integrase by strand transfer in vitro assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM506(3-({4-[bis(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory concentration against purified recombinant integrase by 3'-processing in vitro assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM506(3-({4-[bis(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]...)
Affinity DataIC50:  800nMAssay Description:Integration of DNA by HIV -1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM506(3-({4-[bis(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory activity against 3'-processing of DNA by HIV-1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)TBA
LigandPNGBDBM506(3-({4-[bis(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]...)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM506(3-({4-[bis(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant NQO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)TBA
LigandPNGBDBM506(3-({4-[bis(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory activity against HIV-1 Protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 2)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM506(3-({4-[bis(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against HIV-2 Integrase was measured using 3'-processing (3'-proc) assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM506(3-({4-[bis(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory activity against HIV-1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM506(3-({4-[bis(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity against topoisomerase I.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM506(3-({4-[bis(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human recombinant NQO1 in presence of BSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed