BDBM50600343 CHEMBL5196338

SMILES O=c1ccc2cc(Oc3ccc(cc3)C#N)ccc2n1CCN1CCCCC1

InChI Key InChIKey=KEFLKWVDEZWQCI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50600343   

TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50600343(CHEMBL5196338)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant human Nav 1.7 expressed in HEK293F cells incubated for 3 mins by FRET based membrane potential assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50600343(CHEMBL5196338)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of hERG channel by electrophysiologyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50600343(CHEMBL5196338)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of recombinant human Nav1.2 expressed in HEK293 cells incubated for 3 mins by FRET based membrane potential assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50600343(CHEMBL5196338)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human Nav 1.5 expressed in HEK293 cells at -90 mV holding potential by Whole cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50600343(CHEMBL5196338)
Affinity DataIC50:  80nMAssay Description:Inhibition of human Nav1.8 by FRET based membrane potential assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50600343(CHEMBL5196338)
Affinity DataIC50:  2.28E+3nMAssay Description:Inhibition of recombinant human Nav 1.7 expressed in HEK293F cells at -65 mV holding potential by Qpatch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed