BDBM50600343 CHEMBL5196338
SMILES O=c1ccc2cc(Oc3ccc(cc3)C#N)ccc2n1CCN1CCCCC1
InChI Key InChIKey=KEFLKWVDEZWQCI-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50600343
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human Nav 1.7 expressed in HEK293F cells incubated for 3 mins by FRET based membrane potential assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of hERG channel by electrophysiologyMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of recombinant human Nav1.2 expressed in HEK293 cells incubated for 3 mins by FRET based membrane potential assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human Nav 1.5 expressed in HEK293 cells at -90 mV holding potential by Whole cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of human Nav1.8 by FRET based membrane potential assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.28E+3nMAssay Description:Inhibition of recombinant human Nav 1.7 expressed in HEK293F cells at -65 mV holding potential by Qpatch clamp electrophysiology methodMore data for this Ligand-Target Pair