BDBM50601567 CHEMBL5206565
SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.N\C(NCCCc1nnc(N)s1)=N/C(=O)NCc1ccccc1
InChI Key InChIKey=JQNCPAZRLLSTTQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 47 hits for monomerid = 50601567
Affinity DataKi: 5nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair
Affinity DataKi: 1.38E+3nMAssay Description:Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scint...More data for this Ligand-Target Pair
Affinity DataKi: 2.63E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 140 min...More data for this Ligand-Target Pair
Affinity DataKi: 5.37E+3nMAssay Description:Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incuba...More data for this Ligand-Target Pair
Affinity DataKi: 6.31E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 long receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 14...More data for this Ligand-Target Pair
Affinity DataKi: <1.00E+4nMAssay Description:Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 an...More data for this Ligand-Target Pair
Affinity DataKi: <1.00E+4nMAssay Description:Displacement of [3H]UR-PI294 from human histamine H3 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and ...More data for this Ligand-Target Pair
Affinity DataEC50: 3.30nMAssay Description:Agonist activity at human histamine H2 receptor stably expressed in HEK293T cells co-expressing NlucN-mGs/hH2R-NlucC assessed as induction of mini-Gi...More data for this Ligand-Target Pair
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: 2.20nMAssay Description:Agonist activity at guinea pig histamine H2 receptor stably transfected in HEK293T cells co-expressing NlucN-mGs/gpH2R-NlucC by mini-G protein recrui...More data for this Ligand-Target Pair
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: 1.30nMAssay Description:Agonist activity at histamine H2 receptor in spontaneous beating guinea pig right atrium assessed as increase in heart beatMore data for this Ligand-Target Pair
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist activity at human D2 long receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD2longR-ElucC by beta-arrestin2 recruitmen...More data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+3nMAssay Description:Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.230nMAssay Description:Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scint...More data for this Ligand-Target Pair
Affinity DataKd: 0.0780nMAssay Description:Displacement of [3H]N-methylspiperone from human D4.4 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD4.4R-ELuc incubated f...More data for this Ligand-Target Pair
Affinity DataEC50: 676nMAssay Description:Displacement of [3H]N-methylspiperone from human D4.4 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD4.4R-ELuc incubated f...More data for this Ligand-Target Pair
Affinity DataKd: 0.240nMAssay Description:Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scint...More data for this Ligand-Target Pair
Affinity DataEC50: 1.12E+4nMAssay Description:Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scint...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKd: 0.120nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M3 receptor stably expressed in CHO cells by radioligand competition bind...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: <1.00E+4nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M3 receptor stably expressed in CHO cells by radioligand competition bind...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKd: 0.170nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M1 receptor stably expressed in CHO cells by radioligand competition bind...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: <1.00E+4nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M1 receptor stably expressed in CHO cells by radioligand competition bind...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKd: 0.100nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition bind...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: <1.00E+4nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition bind...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKd: 0.0520nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M4 receptor stably expressed in CHO cells by radioligand competition bind...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: <3.16E+3nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M4 receptor stably expressed in CHO cells by radioligand competition bind...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKd: 0.200nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M5 receptor stably expressed in CHO cells by radioligand competition bind...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: <1.00E+4nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M5 receptor stably expressed in CHO cells by radioligand competition bind...More data for this Ligand-Target Pair
Affinity DataEC50: 851nMAssay Description:Displacement of [3H]prazosin from human alpha-1A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation c...More data for this Ligand-Target Pair
Affinity DataKd: 0.25nMAssay Description:Displacement of [3H]prazosin from human alpha-1A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation c...More data for this Ligand-Target Pair
Affinity DataEC50: 1.26E+3nMAssay Description:Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation c...More data for this Ligand-Target Pair
Affinity DataKd: 0.600nMAssay Description:Displacement of [3H]RX821002 from human alpha-2A adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation c...More data for this Ligand-Target Pair
Affinity DataEC50: <1.00E+5nMAssay Description:Displacement of [3H]CGP12177 from human beta-1 adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Affinity DataKd: 0.0750nMAssay Description:Displacement of [3H]CGP12177 from human beta-1 adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Affinity DataEC50: 3.98E+4nMAssay Description:Displacement of [3H]CGP12177 from human beta-2 adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Affinity DataKd: 0.0700nMAssay Description:Displacement of [3H]CGP12177 from human beta-2 adrenergic receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Affinity DataEC50: 3.98E+3nMAssay Description:Displacement of [3H]diprenorphine from human mu-opioid receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counti...More data for this Ligand-Target Pair
Affinity DataKd: 0.0900nMAssay Description:Displacement of [3H]diprenorphine from human mu-opioid receptor stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counti...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: 2.75E+4nMAssay Description:Displacement of [3H]WAY600135 from human 5HT1A stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKd: 0.0800nMAssay Description:Displacement of [3H]WAY600135 from human 5HT1A stably expressed in HEK293T cell membrane incubated for 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 138nMAssay Description:Agonist activity at human histamine H2 receptor stably expressed in HEK293T cells co-expressing ARRB2 incubated for 60 mins by beta-arrestin2 recruit...More data for this Ligand-Target Pair
Affinity DataKd: 0.0258nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 140 min...More data for this Ligand-Target Pair
Affinity DataKd: 0.0149nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 long receptor stably expressed in HEK293T cells co-expressing luciferase and CEK at high concentr...More data for this Ligand-Target Pair
Affinity DataKd: 0.0149nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 long receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 14...More data for this Ligand-Target Pair
Affinity DataKd: 16nMAssay Description:Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 an...More data for this Ligand-Target Pair
Affinity DataKd: 3nMAssay Description:Displacement of [3H]UR-PI294 from human histamine H3 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and ...More data for this Ligand-Target Pair
Affinity DataKd: 4.5nMAssay Description:Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incuba...More data for this Ligand-Target Pair
Affinity DataKd: 12nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair