BDBM50601754 CHEMBL5208861::US11773078, Example 207

SMILES CN1CCN(CC1)c1ncc(Oc2cc(CN3CCC(CC(O)=O)CC3)cc(n2)-c2cc(Cl)cc(Cl)c2)cn1

InChI Key InChIKey=AZEJIKZNBHEXCM-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50601754   

TargetFurin(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50601754(CHEMBL5208861 | US11773078, Example 207)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
TargetFurin [108-574](Homo sapiens (Human))
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM50601754(CHEMBL5208861 | US11773078, Example 207)
Affinity DataIC50:  0.794nMAssay Description:Reactions were performed in black 384-well polystyrene low volume plates (Greiner). Furin (108-574-Tev-Flag-His) enzyme was expressed and purified fr...More data for this Ligand-Target Pair
In DepthDetails US Patent