BDBM50603811 CHEMBL5171560

SMILES [#6]-[#6]-n1c2nc(-[#6])ccc2c2-[#8][C@@]([#6])([#6]-[#6]-[#8])[#6]-[#6@@H](\[#6]=[#6](\[#6])-[#6])-c2c1=O

InChI Key InChIKey=IOKJCBWLGAJZFW-VFNWGFHPSA-N

Data  11 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50603811   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
National-Local Joint Engineering Laboratory Of Druggability And New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50:  1.76E+3nMAssay Description:Inhibition of PDE10A2 (449 to 770 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
National-Local Joint Engineering Laboratory Of Druggability And New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50:  2.13E+3nMAssay Description:Inhibition of PDE7A1 (130 to 482 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
National-Local Joint Engineering Laboratory Of Druggability And New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50:  4.25E+3nMAssay Description:Inhibition of PDE5A1 (535 to 860 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
National-Local Joint Engineering Laboratory Of Druggability And New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
National-Local Joint Engineering Laboratory Of Druggability And New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of PDE4B2 (152 to 487 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
National-Local Joint Engineering Laboratory Of Druggability And New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of hERG by Q patch automated patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
National-Local Joint Engineering Laboratory Of Druggability And New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50:  1.51E+3nMAssay Description:Inhibition of PDE2A (580 to 919 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
National-Local Joint Engineering Laboratory Of Druggability And New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE3A (679 to 1087 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
National-Local Joint Engineering Laboratory Of Druggability And New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50:  820nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
National-Local Joint Engineering Laboratory Of Druggability And New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE9A2 (181 to 506 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
National-Local Joint Engineering Laboratory Of Druggability And New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1B (10 to 487 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 15...More data for this Ligand-Target Pair
In DepthDetails PubMed