BDBM50605060 CHEMBL5198290::US11891386, Compound 004

SMILES CNC(=O)c1csc(n1)C(=O)c1c[nH]c2ccccc12

InChI Key InChIKey=GOVAEEIQDCTMOG-UHFFFAOYSA-N

Data  2 KI  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50605060   

TargetAryl hydrocarbon receptor(Mus musculus (Mouse))
Palack£

Curated by ChEMBL
LigandPNGBDBM50605060(CHEMBL5198290 | US11891386, Compound 004)
Affinity DataKi:  88nMAssay Description:Displacement of [3H]TCDD from mouse AhR expressed in mouse Hepa1c1c7 cells cytosol incubated for 2 hrs by competitive radioligand binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAryl hydrocarbon receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50605060(CHEMBL5198290 | US11891386, Compound 004)
Affinity DataKi:  88nMAssay Description:Binding affinity to AhR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Palack£

Curated by ChEMBL
LigandPNGBDBM50605060(CHEMBL5198290 | US11891386, Compound 004)
Affinity DataEC50:  1.20E+4nMAssay Description:Agonist activity at human PXR transfected in human LS180 cells cotransfected with luciferase reporter plasmid p2A4-Luc assessed as transcriptional ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAryl hydrocarbon receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50605060(CHEMBL5198290 | US11891386, Compound 004)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at AhR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-21(Homo sapiens (Human))
Ariagen

US Patent
LigandPNGBDBM50605060(CHEMBL5198290 | US11891386, Compound 004)
Affinity DataIC50:  231nMAssay Description:IL-21 levels in cell supernatants and cell-free control samples were measured using the ALPHALISA assay kit from Perkin Elmer, following the manufact...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAryl hydrocarbon receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50605060(CHEMBL5198290 | US11891386, Compound 004)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at AhR (unknown origin) transfected in human AZ-AHR reporter cells derived from human HepG2 cells incubated for 4 hrs by luciferase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Palack£

Curated by ChEMBL
LigandPNGBDBM50605060(CHEMBL5198290 | US11891386, Compound 004)
Affinity DataIC50:  3.21E+4nMAssay Description:Displacement of fluorescence labeled ligand from human PXR ligand binding domain by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed