BDBM50606386 CHEMBL5182207

SMILES CC[C@H](C)[C@H](N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CCCNS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)N1CCC[C@H]1CC(N)=O

InChI Key InChIKey=HUAZIQKZKFNJLA-YSEMLTDISA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50606386   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606386(CHEMBL5182207)
Affinity DataIC50:  0.0550nMAssay Description:Inhibition of recombinant human MMP2 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as a substrate preincubated for 15 mins followed by substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606386(CHEMBL5182207)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of recombinant human MMP12 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606386(CHEMBL5182207)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant human MMP13 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606386(CHEMBL5182207)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human MMP1 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606386(CHEMBL5182207)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human MMP14 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMatrilysin(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606386(CHEMBL5182207)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of recombinant human MMP7 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606386(CHEMBL5182207)
Affinity DataIC50:  261nMAssay Description:Inhibition of recombinant human MMP8 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606386(CHEMBL5182207)
Affinity DataIC50:  181nMAssay Description:Inhibition of recombinant human MMP9 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetStromelysin-1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606386(CHEMBL5182207)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human MMP3 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-N2 as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed