BDBM50606679 CHEMBL5218636

SMILES OC(=O)CNC(=O)c1nc(ccc1O)-c1cccc2ccccc12

InChI Key InChIKey=CQPTZSBTFPQERZ-UHFFFAOYSA-N

Data  7 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50606679   

TargetLysine-specific demethylase 6B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50606679(CHEMBL5218636)
Affinity DataIC50:  7.64E+4nMAssay Description:Inhibition of human KDM6B preincubated for 15 mins followed by substrate addition and measured after 5 mins using H3(21-44)K27Me3-GK-biotin peptide a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50606679(CHEMBL5218636)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO demethylation activity expressed in Escherichia coli BL21 (DE3) incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50606679(CHEMBL5218636)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO demethylation activity expressed in Escherichia coli BL21 (DE3) incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50606679(CHEMBL5218636)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 by competition-based NMR bin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50606679(CHEMBL5218636)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human KDM4C preincubated for 15 mins followed by substrate addition and measured after 15 mins using H3(1-21)K9Me3-GGK-Biotin peptide a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50606679(CHEMBL5218636)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human KDM5B preincubated for 15 mins followed by substrate addition and measured after 20 mins using H3(1-21)K4Me3-GGK-Biotin peptide a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetLysine-specific demethylase 2A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50606679(CHEMBL5218636)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human KDM2A preincubated for 15 mins followed by substrate addition and measured after 30 mins using Biotin-H3(28-48)K36Me2 peptide as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetLysine-specific demethylase 3A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50606679(CHEMBL5218636)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human KDM3A preincubated for 15 mins followed by substrate addition and measured after 5 mins using H3(1-21)K9Me2-GGK-Biotin peptide as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed