BDBM50607509 CHEMBL5219789

SMILES CN[C@@H]1COc2c(cnn2C1)S(=O)(=O)NC(=O)Nc1c2CCCc2cc2CCCc12

InChI Key InChIKey=NDRARVKETDZHBS-AWEZNQCLSA-N

Data  14 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50607509   

TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and nigericin-stimulated human PBMC cells assessed as reduction in IL-1beta release preincubated w...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50:  400nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and ATP-stimulated human whole blood assessed as reduction in IL-1beta release in plasma preincuba...More data for this Ligand-Target Pair
TargetNLR family CARD domain-containing protein 4(Homo sapiens)
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of NLRC4 inflammasome activation in LPS/flagellin-treated human THP-1 cells preincubated with LPS for 3 hrs followed by compound addition ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50:  51nMAssay Description:Inhibition of NLRP3 induced caspase 1 activity in LPS/nigericin-treated human THP-1 cells preincubated with LPS for 3 hrs followed by compound additi...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50:  63nMAssay Description:Inhibition of NLRP3 induced IL-1beta release in LPS/nigericin-treated mouse BMDM cells preincubated with LPS for 3 hrs followed by compound addition ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50:  48nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS/nigericin stimulated human THP1-ASC-GFP cells assessed as decrease in ASC speck formation preincub...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50:  17nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human monocyte-derived macrophage assessed as reduction in IL-18 secretion in presence ...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50:  100nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and ATP-stimulated mouse whole blood assessed as reduction in IL-1beta release preincubated for 3 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50:  380nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human whole blood assessed as reduction in ILbeta secretion in presence of monosodium u...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50:  490nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human whole blood assessed as reduction in ILbeta secretion in presence of cholesterol ...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50:  290nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human whole blood assessed as reduction in ILbeta secretion in presence of calcium pyro...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50:  17nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human monocyte-derived macrophage assessed as reduction in ILbeta secretion in presence...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50:  17nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human monocyte-derived macrophage assessed as reduction in IL-18 secretion in presence ...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics

Curated by ChEMBL
LigandPNGBDBM50607509(CHEMBL5219789)
Affinity DataIC50:  16nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human monocyte-derived macrophage assessed as reduction in ILbeta secretion in presence...More data for this Ligand-Target Pair