BDBM50607678 CHEMBL5218878

SMILES Nc1nc(Cl)cc(n1)-c1nn(cc1Cc1ccccc1OCCN1CCNC(=O)C1)C(F)F

InChI Key InChIKey=MWXPBEVQULPVTM-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50607678   

TargetAdenylate cyclase type 10(Homo sapiens (Human))
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607678(CHEMBL5218878)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Homo sapiens (Human))
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607678(CHEMBL5218878)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to human recombinant His-tagged ADCY10 assessed as dissociation constant and measured for 600 sec by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Rattus norvegicus)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607678(CHEMBL5218878)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of rat ADCY10 overexpressed in rat 4-4 cells assessed as IBMX stimulated cAMP accumulation preincubated for 10 mins followed by IBMX stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed