BDBM50610969 CHEMBL5278302

SMILES CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O

InChI Key InChIKey=UDCAKLDMNJRQKW-UHFFFAOYSA-N

Data  2 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50610969   

TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))TBA
LigandPNGBDBM50610969(CHEMBL5278302)
Affinity DataKi:  4.27E+3nMAssay Description:Competitive inhibition of human recombinant N-terminal His6-tagged eIF4A expressed in Escherichia coli BL21 CodonPlus cells using 250 uM ATP and vary...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))TBA
LigandPNGBDBM50610969(CHEMBL5278302)
Affinity DataKi:  4.79E+3nMAssay Description:Uncompetitive inhibition of human recombinant N-terminal His6-tagged eIF4A expressed in Escherichia coli BL21 CodonPlus cells using varying concentra...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))TBA
LigandPNGBDBM50610969(CHEMBL5278302)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged eIF4A R110M mutant expressed in Escherichia coli BL21 CodonPlus cells using ATP and yeast RNA ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))TBA
LigandPNGBDBM50610969(CHEMBL5278302)
Affinity DataIC50:  6.58E+3nMAssay Description:Inhibition of helicase activity of human recombinant N-terminal His6-tagged eIF4A expressed in Escherichia coli BL21 CodonPlus cells using Cy3-labele...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))TBA
LigandPNGBDBM50610969(CHEMBL5278302)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged eIF4A T158A mutant expressed in Escherichia coli BL21 CodonPlus cells using ATP and yeast RNA ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))TBA
LigandPNGBDBM50610969(CHEMBL5278302)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged eIF4A T158V mutant expressed in Escherichia coli BL21 CodonPlus cells using ATP and yeast RNA ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))TBA
LigandPNGBDBM50610969(CHEMBL5278302)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged eIF4A R311K mutant expressed in Escherichia coli BL21 CodonPlus cells using ATP and yeast RNA ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))TBA
LigandPNGBDBM50610969(CHEMBL5278302)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged eIF4A R311E mutant expressed in Escherichia coli BL21 CodonPlus cells using ATP and yeast RNA ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))TBA
LigandPNGBDBM50610969(CHEMBL5278302)
Affinity DataIC50:  5.83E+4nMAssay Description:Displacement of FAM-A-[CAA]5 from human recombinant N-terminal His6-tagged eIF4A expressed in Escherichia coli BL21 CodonPlus cells preincubated with...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))TBA
LigandPNGBDBM50610969(CHEMBL5278302)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged eIF4A R110L mutant expressed in Escherichia coli BL21 CodonPlus cells using ATP and yeast RNA ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))TBA
LigandPNGBDBM50610969(CHEMBL5278302)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged eIF4A expressed in Escherichia coli BL21 CodonPlus cells using ATP and yeast RNA as substrate ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))TBA
LigandPNGBDBM50610969(CHEMBL5278302)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged eIF4A R110E mutant expressed in Escherichia coli BL21 CodonPlus cells using ATP and yeast RNA ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed