BDBM50611048 BAY-091
SMILES CC[C@@H](Nc1c(C#N)c(nc2cnccc12)-c1ccc(cc1)-c1cccc(C)c1F)C(O)=O
InChI Key InChIKey=DVIVLYHDLNAXAT-OAQYLSRUSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50611048
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant full length His-tagged PIP4K2A (unknown origin) expressed in sf21 cells assessed as reduction in ADP production preincubate...More data for this Ligand-Target Pair
Ligand InfoPDB
3D Structure (crystal)Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of human PIP4K2A in human THP-1 cells assessed as increase in mitochondrial ROS level incubated for 1 hrs by MitoSOX Red based flow cytome...More data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant full length His-tagged PIP4K2A (unknown origin) expressed in sf21 cells assessed as reduction in ADP production preincubate...More data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant full length His-tagged PIP4K2A (unknown origin) expressed in sf21 assessed as reduction in PI4,5P2 production preincubated ...More data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human PIP4K2A in human THP-1 cells assessed as increase in Akt phosphorylation at Ser473 residue incubated for 2 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG mediated tail current in HEK293 cells at 10 uM and measured after 5 to 6 mins at -80 mV holding potential by whole cell patch...More data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using dextromethorphan as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes preincubated with compound followed by substrate addition using dextromethorphan as substrate by LC-MS...More data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataEC50: 1.80E+3nMAssay Description:Binding affinity to human PIP4K2A in human THP-1 cell lysate assessed as thermal stability by measuring shift in temperature incubated for 30 mins at...More data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataEC50: 1.10E+3nMAssay Description:Binding affinity to human PIP4K2A in human THP-1 intact cells sessed as thermal stability by measuring shift in temperature incubated for 30 mins at ...More data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant full length His-tagged PIP4K2A (unknown origin) expressed in sf21 assessed as reduction in PI4,5P2 production preincubated ...More data for this Ligand-Target Pair
Ligand InfoPDB