BDBM50612195 CHEMBL5288931

SMILES CN1CCC(CC1)n1cc(Nc2nc(OC3(C)CC3)c3nc(c(F)cc3n2)-c2cnc(C)nc2)cn1

InChI Key InChIKey=SZURKEABSBIIMJ-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50612195   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))TBA
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50:  3nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPDB
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))TBA
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50:  110nMAssay Description:Inhibition of IRAK4 (unknown origin) phosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPDB
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of IRAK1 (unknown origin) in presence of 25 uM ATPMore data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of BTK (unknown origin) in presence of 25 uM ATPMore data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails PubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50:  270nMAssay Description:Inhibition of TRKC (unknown origin) in presence of 50 uM ATPMore data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails PubMed
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50:  53nMAssay Description:Inhibition of PI3Kdelta (unknown origin) in presence of 75 uM ATPMore data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50:  270nMAssay Description:Inhibition of TRKA (unknown origin) in presence of 400 uM ATPMore data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails PubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50:  760nMAssay Description:Inhibition of TRKB (unknown origin) in presence of 25 uM ATPMore data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50612195(CHEMBL5288931)
Affinity DataIC50: >9.00E+3nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of 600 uM ATPMore data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails PubMed