BDBM50614125 CHEMBL5270771

SMILES CC(=O)N1c2cnc(NC(=O)OCc3cccc(Cl)c3)nc2C2(CCC(F)(F)CC2)C1(C)C

InChI Key InChIKey=IANQKTUEKNCKCB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50614125   

TargetThyrotropin receptor(Rattus norvegicus)TBA
LigandPNGBDBM50614125(CHEMBL5270771)
Affinity DataIC50:  27nMAssay Description:Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFollicle-stimulating hormone receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614125(CHEMBL5270771)
Affinity DataIC50:  1.75E+3nMAssay Description:Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614125(CHEMBL5270771)
Affinity DataIC50:  56nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed