BDBM510886 2-cyclopropyl-4- {[(aR)-6-[6-(6- fluoropyridin-3-yl)- 3-(trifluoromethyl) imidazo[1,5-a]pyridine- 1-amido]spiro[3.3] heptan-2-yl]oxy}-1,3- thiazole-5- carboxamide::US11078197, Example 63::US11673886, Example 63

SMILES NC(=O)c1sc(nc1O[C@H]1C[C@@]2(C[C@@H](C2)NC(=O)c2nc(n3cc(ccc23)-c2ccc(F)nc2)C(F)(F)F)C1)C1CC1

InChI Key InChIKey=GAZSECRIOVRHBD-FXUCQVAHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510886   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510886(2-cyclopropyl-4- {[(aR)-6-[6-(6- fluoropyridin-3-y...)
Affinity DataIC50:  6.10nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510886(2-cyclopropyl-4- {[(aR)-6-[6-(6- fluoropyridin-3-y...)
Affinity DataIC50:  6.10E+3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent