BDBM510923 1-methyl-6-{[(aR)-6-(3- cyanobenzamido) spiro[3.3]heptan-2- yl]oxy}-1H- pyrazolo[3,4- b]pyridine-5- carboxamide::US11078197, Example 102::US11673886, Example 102

SMILES Cn1ncc2cc(C(N)=O)c(O[C@H]3C[C@@]4(C[C@@H](C4)NC(=O)c4cccc(c4)C#N)C3)nc12

InChI Key InChIKey=HNNUVEBZNMIFHK-QQMNAOGKSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510923   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510923(1-methyl-6-{[(aR)-6-(3- cyanobenzamido) spiro[3.3]...)
Affinity DataIC50:  8nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510923(1-methyl-6-{[(aR)-6-(3- cyanobenzamido) spiro[3.3]...)
Affinity DataIC50:  8.00E+3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent