BDBM510954 1-(difluoromethyl)-6-(2- hydroxy-2- methylpropoxy)-N-[(4s)-6- ({3-carbamoyl-7- methylpyrazolo[1,5- a]pyridin-2- yl}oxy)spiro[3.3]heptan-2- yl]-1H-indazole-3- carboxamide::US11078197, Example 133::US11673886, Example 133

SMILES Cc1cccc2c(C(N)=O)c(O[C@H]3C[C@@]4(C[C@@H](C4)NC(=O)c4nn(C(F)F)c5cc(OCC(C)(C)O)ccc45)C3)nn12

InChI Key InChIKey=NRARBUYYXAEABB-ZVXFEBSPSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510954   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510954(1-(difluoromethyl)-6-(2- hydroxy-2- methylpropoxy)...)
Affinity DataIC50:  20.2nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510954(1-(difluoromethyl)-6-(2- hydroxy-2- methylpropoxy)...)
Affinity DataIC50:  2.02E+4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent