BDBM515342 US11110088, Compound Table 1.16

SMILES COC\C=C\C(=O)N[C@@H](C)c1nc(-c2ccc(C(=O)Nc3ccc(C)cn3)c(OC)c2)c2c(N)nccn12

InChI Key InChIKey=XXJWOZLYIDMCJH-RTRPANQVSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 515342   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM515342(US11110088, Compound Table 1.16)
Affinity DataIC50:  3.90nMAssay Description:BTK enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.BTK enzyme (H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM515342(US11110088, Compound Table 1.16)
Affinity DataIC50: >1.00E+3nMAssay Description:EGFR enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.EGFR enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM515342(US11110088, Compound Table 1.16)
Affinity DataIC50:  3nMAssay Description:BMX enzyme (Millipore #14-499M), is diluted to 0.5 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.1% NaN3, 1 mM DTT, 2 mM MnCl2, p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM515342(US11110088, Compound Table 1.16)
Affinity DataIC50:  2.70nMAssay Description:TXK enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.TXK enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM515342(US11110088, Compound Table 1.16)
Affinity DataIC50: >1.00E+3nMAssay Description:ITK enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.ITK enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM515342(US11110088, Compound Table 1.16)
Affinity DataIC50:  1.60nMAssay Description:TEC enzyme (Millipore #14-801M), is diluted to 2 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.1% NaN3, 1 mM DTT, 2 mM MnCl2, pH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent