BDBM515346 (13E,14E)-12-amino-35-fluoro-4-oxa-8-aza-1 (5,3)-pyrazolo[1,5-alpyrimidine-3(3,2)- pyridine-2(1,2)-pyrrolidylcyclononanephane- 9-one::US11098060, Example 2

SMILES Nc1nn2ccc3nc2c1C(=O)NCCCOc1ncc(F)cc1C1CCCN31

InChI Key InChIKey=KTUNZGUQLKAYLZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515346   

TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515346((13E,14E)-12-amino-35-fluoro-4-oxa-8-aza-1 (5,3)-p...)
Affinity DataIC50:  1.86nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515346((13E,14E)-12-amino-35-fluoro-4-oxa-8-aza-1 (5,3)-p...)
Affinity DataIC50:  0.570nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent