BDBM515348 (R,13E,14E)-12-amino-4-oxa-7-aza-1(5,3)- pyrazolo[1,5-a]pyrimidine-3(3,2)-pyridine-2 (1,2)-pyrrolidylcyclooctanephane-8-one::US11098060, Example 5

SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ncccc1[C@H]1CCCN31

InChI Key InChIKey=RJMYCFOIEDXDKQ-GFCCVEGCSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515348   

TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515348((R,13E,14E)-12-amino-4-oxa-7-aza-1(5,3)- pyrazolo[...)
Affinity DataIC50:  12.1nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515348((R,13E,14E)-12-amino-4-oxa-7-aza-1(5,3)- pyrazolo[...)
Affinity DataIC50:  0.370nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent