BDBM515350 (R,13E,14E)-12-amino-35-fluro-4-oxa-7-aza- 1(5,3)-pyrazolo[1,5-a]pyrimidine-2(1,2)- pyrrolidine-3(1,2)-benzocyclooctanephane-8- one::US11098060, Example 8

SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ccc(F)cc1[C@H]1CCCN31

InChI Key InChIKey=UHQIWVJXLBNEIY-CYBMUJFWSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 515350   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515350((R,13E,14E)-12-amino-35-fluro-4-oxa-7-aza- 1(5,3)-...)
Affinity DataIC50:  0.410nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G595R](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515350((R,13E,14E)-12-amino-35-fluro-4-oxa-7-aza- 1(5,3)-...)
Affinity DataIC50:  2.08nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515350((R,13E,14E)-12-amino-35-fluro-4-oxa-7-aza- 1(5,3)-...)
Affinity DataIC50:  1.63nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent