BDBM515353 (13E, 14E)-12-amino-4-oxa-7-aza-1(5,3)- pyrazolo[1,5-a]pyrimidine-3(3,2)-pyridine-2 (1,2)-pyrrolidylcyclooctanephane-8-one::US11098060, Example 11

SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ncccc1C1CCCN31

InChI Key InChIKey=RJMYCFOIEDXDKQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515353   

TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515353((13E, 14E)-12-amino-4-oxa-7-aza-1(5,3)- pyrazolo[1...)
Affinity DataIC50:  17.4nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515353((13E, 14E)-12-amino-4-oxa-7-aza-1(5,3)- pyrazolo[1...)
Affinity DataIC50:  1.04nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent