BDBM515377 (13E,14E,22R,24S)-12-amino- 24,35-difluoro-4-oxa-7-aza-1(5,3)- pyrazolo[1,5-a]pyrimidine- 2(1,2)-pyrrolidine-3(1,2)- benzocyclooctanephane-8-one::US11098060, Example 37

SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ccc(F)cc1[C@H]1C[C@H](F)CN31

InChI Key InChIKey=HOEUBKYMDLQKOB-WCQYABFASA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 515377   

TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515377((13E,14E,22R,24S)-12-amino- 24,35-difluoro-4-oxa-7...)
Affinity DataIC50:  0.210nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent