BDBM515579 US11098063, Example 77::US11098063, Example 78

SMILES COc1ccc(C)c(n1)C(=O)N1CC2CCC1CN2Cc1c(nc2ncccn12)-c1ccc(cc1)C(C)C

InChI Key InChIKey=DMKQQNXPDITBNA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 515579   

TargetPotassium channel subfamily K member 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM515579(US11098063, Example 77 | US11098063, Example 78)
Affinity DataIC50:  720nMAssay Description:Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium channel subfamily K member 9(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM515579(US11098063, Example 77 | US11098063, Example 78)
Affinity DataIC50:  24nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were conducted using stably transfected CHO cells. The compounds a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium channel subfamily K member 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM515579(US11098063, Example 77 | US11098063, Example 78)
Affinity DataIC50:  3.80E+3nMAssay Description:Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium channel subfamily K member 9(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM515579(US11098063, Example 77 | US11098063, Example 78)
Affinity DataIC50:  4.90nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were conducted using stably transfected CHO cells. The compounds a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent