BDBM515905 N-(5-((4-ethylpiperazin- 1-yl)methyl) pyridin-2-yl)-5- fluoro-4-(6- fluoro-1-methyl- 1,2,3,4-tetrahydrobenzo [4,5]imidazo[l,2- a]pyridin- 8-yl)pyrimidin-2-amine::US11053238, Example 2

SMILES CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCCC(C)n5c4c3)nc2)CC1

InChI Key InChIKey=XOJPAVACYRFOBK-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 515905   

TargetCyclin-A2 [177-432]/Cyclin-dependent kinase 2(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515905(N-(5-((4-ethylpiperazin- 1-yl)methyl) pyridin-2-yl...)
Affinity DataIC50: >300nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515905(N-(5-((4-ethylpiperazin- 1-yl)methyl) pyridin-2-yl...)
Affinity DataIC50:  2nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515905(N-(5-((4-ethylpiperazin- 1-yl)methyl) pyridin-2-yl...)
Affinity DataIC50:  31nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515905(N-(5-((4-ethylpiperazin- 1-yl)methyl) pyridin-2-yl...)
Affinity DataIC50:  572nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515905(N-(5-((4-ethylpiperazin- 1-yl)methyl) pyridin-2-yl...)
Affinity DataIC50:  2.35E+3nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515905(N-(5-((4-ethylpiperazin- 1-yl)methyl) pyridin-2-yl...)
Affinity DataIC50:  474nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515905(N-(5-((4-ethylpiperazin- 1-yl)methyl) pyridin-2-yl...)
Affinity DataIC50:  1.05E+3nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515905(N-(5-((4-ethylpiperazin- 1-yl)methyl) pyridin-2-yl...)
Affinity DataIC50: <10nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent