BDBM517670 NY0460::US11124489, Compound 14

SMILES FC(F)(F)c1cc(NNC(C#N)C(=O)c2cc(on2)-c2ccccc2)ccc1Cl

InChI Key InChIKey=BTTKCEVXSPARTN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 517670   

TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM517670(NY0460 | US11124489, Compound 14)
Affinity DataIC50:  2.30E+3nMAssay Description:From the biological results discussed above, compounds 10, 14-15, 23-24, 26-27, and 31-32 were identified as potent EPAC1 inhibitors with IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM517670(NY0460 | US11124489, Compound 14)
Affinity DataIC50:  2.40E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent