BDBM517681 NY0654::US11124489, Compound 23

SMILES COc1ccc(cc1)-c1cc(no1)C(=O)C(NNc1ccc(Cl)c(c1)C(F)(F)F)C#N

InChI Key InChIKey=GEQOLQXCYZJYSU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 517681   

TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM517681(NY0654 | US11124489, Compound 23)
Affinity DataIC50:  4.50E+3nMAssay Description:From the biological results discussed above, compounds 10, 14-15, 23-24, 26-27, and 31-32 were identified as potent EPAC1 inhibitors with IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM517681(NY0654 | US11124489, Compound 23)
Affinity DataIC50:  5.60E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent