BDBM517684 NY0725::US11124489, Compound 26

SMILES FC(F)(F)c1cc(Cl)cc(NNC(C#N)C(=O)c2cc(on2)-c2ccco2)c1

InChI Key InChIKey=AYXWBPHUOFDFRU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 517684   

TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM517684(NY0725 | US11124489, Compound 26)
Affinity DataIC50:  2.20E+3nMAssay Description:From the biological results discussed above, compounds 10, 14-15, 23-24, 26-27, and 31-32 were identified as potent EPAC1 inhibitors with IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM517684(NY0725 | US11124489, Compound 26)
Affinity DataIC50:  3.60E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent