BDBM517701 US11124489, Entry 15::ZL0479

SMILES CC(C)(C)c1ccc(cc1)C(=O)C(NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C#N

InChI Key InChIKey=DMASTIWDLFDRKN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 517701   

TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM517701(US11124489, Entry 15 | ZL0479)
Affinity DataIC50:  6.30E+3nMAssay Description:From the biological results discussed above, compounds 10, 14-15, 23-24, 26-27, and 31-32 were identified as potent EPAC1 inhibitors with IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM517701(US11124489, Entry 15 | ZL0479)
Affinity DataIC50:  5.50E+3nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent