BDBM518413 2-[(2S,3R)-3-Hydroxy-2-methyl-azetidin-1-yl]-6-[1-(4-piperidyl)pyrazol-4-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile::US11124500, Example 7

SMILES C[C@H]1[C@H](O)CN1c1nc(cc(c1C#N)C(F)(F)F)-c1cnn(c1)C1CCNCC1

InChI Key InChIKey=SYTULTPYWMLMHI-APPDUMDISA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 518413   

TargetIsoform A of Ketohexokinase (Peripheral)(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM518413(2-[(2S,3R)-3-Hydroxy-2-methyl-azetidin-1-yl]-6-[1-...)
Affinity DataIC50:  6.02nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKetohexokinase(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM518413(2-[(2S,3R)-3-Hydroxy-2-methyl-azetidin-1-yl]-6-[1-...)
Affinity DataIC50:  18.1nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent